4-[4-(乙氧羰酰)-1,3-噻唑-2-YL]四氢-1(2H)-吡啶羧酸叔丁酯合成路线 （共 7 条）
反应条件
1: in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 2: With triethylamine in DMF (N,N-dimethyl-formamide)
参考文献
METRIS THERAPEUTICS LIMITED
Patent: WO2004/58750 A1, 2004 ;
Location in patent: Page 31-32; 30 ;
反应条件
manganese(IV) oxide in toluene T=70°C; 5 h;
参考文献
4SC AG
Patent: EP1834954 A1, 2007 ;
Location in patent: Page/Page column 21 ;
EP 1834954 A1
反应条件
acetic acid T=100°C; 1.5 h;
参考文献
Merck Patent Gesellschaft Mit Beschrankter Haftling
Patent: US2011/60007 A1, 2011 ;
Location in patent: Page/Page column 20 ;
US 20110060007 A1
反应条件
1: sodium acetate / ethyl acetate / 16 h / 5 °C 2: acetic acid / 1.5 h / 100 °C View Scheme
参考文献
US2011/60007 A1, ;
US 20110060007 A1
反应条件
1: sodium acetate / ethyl acetate / 16 h / 5 °C 2: acetic acid / 1.5 h / 100 °C View Scheme
参考文献
US2011/60007 A1, ;
US 20110060007 A1
反应条件
1: With sodium hydroxide; water in 1,4-dioxane
T=20°C; 2.16667 h;
2: With hydrogenchloride in 1,4-dioxane
参考文献
4SC AG
Patent: EP1834954 A1, 2007 ;
Location in patent: Page/Page column 21 ;
EP 1834954 A1
反应条件
methanol; lithium borohydride in tetrahydrofuran
T=20°C; 16 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00312 ;
