4-溴-1-甲基-1H-吲唑合成路线 （共 7 条）
反应条件
in dimethyl sulfoxide T=85°C; 24 h;
参考文献
WO2008/24945 A1, ;
Page/Page column 29 ;
WO 2008/024945 A1
反应条件
potassium carbonate in acetone Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5296 - 5304
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1.92 h / -70 °C 1.2: 20 °C 2.1: dimethyl sulfoxide / 24 h / 20 - 85 °C View Scheme
参考文献
US2012/245163 A1, ;
US 20120245163 A1
反应条件
1.1: tetrafluoroboric acid; sodium nitrite / water / 3 h / 0 - 20 °C 1.2: 2 h / 20 °C 2.1: potassium carbonate / acetone / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5296 - 5304
反应条件
1: With N-(diphenylmethylene)amine; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene T=20°C; 0.25 h; Inert atmosphere; 2: With sodium t-butanolate in toluene T=80 - 85°C; 2 h; Inert atmosphere;
参考文献
WO2010/45401 A1, ;
Page/Page column 38 ;
WO 2010/045401 A1
反应条件
1: With N-(diphenylmethylene)amine; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene T=20°C; 0.333333 h; Inert atmosphere; 2: With sodium t-butanolate in toluene T=80 - 85°C; 2 h; Inert atmosphere;
参考文献
ABBOTT LABORATORIES
Patent: US2012/245163 A1, 2012 ;
Location in patent: Page/Page column 35 ;
US 20120245163 A1
反应条件
potassium fluoride; C114H158O4P2Pd2; silver fluoride in tert-butyl methyl ether T=110°C; 14 h; Sealed tube;
参考文献
Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 3792 - 3795
