1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 0.5 h; 2: 4-fluoro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; 3: With water in tetrahydrofuran; hexane T=20°C;

1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: 1-(4-fluorobenzoyl)-2-methylaziridine in tetrahydrofuran; hexane T=-78 - 20°C;

1: 82 percent / Br2; AcOH / 3 h / 80 °C 2: 76 percent / dimethylformamide / 14 h / 20 °C View Scheme