3-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1-[三s(1-甲基乙基)甲硅烷基]-1H-吡咯合成路线 （共 14 条）
反应条件
Et3N in dichloromethane byproducts: Et3NH-AlCl4; to borenium cation made in situ (in Schlenk, to soln. Et2N (CH2Cl2) added CatBCl, AlCl3; stirred) at 20°C arene added (CH2Cl2); excess Et3N added; pinacol added; stirred for 32 h;; (11)B (1H) NMR; volatiless remowed under vac; extracted (hexane); filtered through silica; removal of solvent;;
参考文献
Del Grosso, Alessandro; Singleton, Paul J.; Muryn, Christopher A.; Ingleson, Michael J.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 9 p. 2102 - 2106
反应条件
AlCl3; 2,6-lutidine in dichloromethane 1:1 mixt. of BCl3 and AlCl, pinacol (2.3-3.0 equiv.) and lutidine (15 equiv.) for 14 h;
参考文献
Del Grosso, Alessandro; Helm, Matthew D.; Solomon, Sophia A.; Caras-Quintero, Dolores; Ingleson, Michael J.
Chemical Communications, 2011 , vol. 47, # 46 p. 12459 - 12461
反应条件
1: chlorocatecholborane; 1-(Triisopropylsilyl)pyrrole With AlCl3, aluminium chloride; tri-cyclo-hexyl-phosphine in dichloromethane Inert atmosphere; 2: 2,3-dimethylbutane-2,3-diol With triethylamine in dichloromethane Irradiation; Product distribution / selectivity;
参考文献
WO2012/25760 A1, ;
Page/Page column 62-63 ;
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in hexane; water; butan-1-ol T=100°C; Suzuki coupling; 2 h;
参考文献
Beck, Elizabeth M.; Hatley, Richard; Gaunt, Matthew J.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 16 p. 3004 - 3007
