2-氨基-6,7-二氢噻唑并[5,4-c]吡啶-5(4H)-甲酸叔丁酯合成路线 （共 14 条）
反应条件
tert.-butylnitrite; copper(ll) bromide in N,N-dimethyl-formamide T=50 - 60°C; 2 h;
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
反应条件
tert.-butylnitrite in N,N-dimethyl-formamide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: US2005/20645 A1, 2005 ;
反应条件
1: 49 percent / t-BuONO; CuBr2 / dimethylformamide / 2 h / 50 - 60 °C 2: TFA / CH2Cl2 / 0.17 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 63, # 7 p. 1555 - 1561
反应条件
1: 49 percent / t-BuONO; CuBr2 / dimethylformamide / 2 h / 50 - 60 °C 2: TFA / CH2Cl2 / 0.17 h / 20 °C 3: 49.0 g / NaBH(OAc)3; Et3N; AcOH / H2O; CH2Cl2; diethyl ether / 1 h / 20 °C View Scheme
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
