2-溴-6,7-二氢噻唑并[5,4-c]吡啶-5(4H)-羧酸叔丁酯合成路线 （共 6 条）
反应条件
tert.-butylnitrite; copper(ll) bromide in N,N-dimethyl-formamide T=50 - 60°C; 2 h;
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
反应条件
tert.-butylnitrite in N,N-dimethyl-formamide
反应条件
1.1: pyrrolidine; TsOH*H2O / cyclohexane / 2 h / Heating 1.2: 63 percent / S8 / methanol / 5 h / 0 °C 2.1: 49 percent / t-BuONO; CuBr2 / dimethylformamide / 2 h / 50 - 60 °C View Scheme
参考文献
Heterocycles, , vol. 63, # 7 p. 1555 - 1561
反应条件
1: isopropyl alcohol / 1 h / Reflux 2: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 0 °C View Scheme
参考文献
WO2012/29070 A1, ;
WO 2012/029070 A1
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 24 p. 7337 - 7343
反应条件
1: TFA / CH2Cl2 / 0.17 h / 20 °C 2: 49.0 g / NaBH(OAc)3; Et3N; AcOH / H2O; CH2Cl2; diethyl ether / 1 h / 20 °C View Scheme
参考文献
Haginoya, Noriyasu; Komoriya, Satoshi; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Nagamochi, Masatoshi; Muto, Ryo; Yamaguchi, Mitsuhiro; Nagahara, Takayasu; Kanno, Hideyuki
Heterocycles, 2004 , vol. 63, # 7 p. 1555 - 1561
