4-氟-N-苯基苯甲酰胺合成路线 （共 23 条）
反应条件
(benzyldiphenylphosphine)2PdCl2; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=130°C; P=6205.94 Torr; 0.333333 h; Microwave irradiation;
参考文献
Cardullo, Francesca; Donati, Daniele; Merlo, Giancarlo; Paio, Alfredo; Petricci, Elena; Taddei, Maurizio
Synlett, 2009 , # 1 p. 47 - 50
反应条件
bromo-dimethylsulfonium bromide
T=80°C; Beckmann rearrangement; 3 h; Ionic liquid;
参考文献
Yadav, Lal Dhar S.; Garima; Srivastava, Vishnu P.
Tetrahedron Letters, 2010 , vol. 51, # 4 p. 739 - 743
反应条件
nonafluoro-n-butanesulfonyl fluoride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine in acetonitrile
T=80°C; 16 h; Schlenk techniqueInert atmosphere;
参考文献
Li, Haoquan; Neumann, Helfried; Beller, Matthias; Wu, Xiao-Feng
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3183 - 3186
Angew. Chem., 2014 , vol. 126, # 12 p. 3247 - 3250,4
反应条件
copper(l) iodide; (E)-1-(2-hydroxyphenyl)-3-(N,N-dimethylamino)prop-2-en-1-one; caesium carbonate in acetonitrile
T=82°C; Goldberg type reaction; 12 h; Inert atmosphere;
参考文献
Cheng, Cungui; Sun, Gonglei; Wan, Jieping; Sun, Cuirong
Synlett, 2009 , # 16 p. 2663 - 2668
反应条件
oxygen; potassium hydroxide in water
T=50°C; 12 h; Green chemistry;
参考文献
Guo, Xuefeng; Tang, Lin; Yang, Yu; Zha, Zhenggen; Wang, Zhiyong
Green Chemistry, 2014 , vol. 16, # 5 p. 2443 - 2447
反应条件
1: 100 percent / hydroxylamine hydrochloride; sodium acetate trihydrate / aq. methanol / Heating
2: mercury(II) chloride / acetonitrile / 8 h / 80 °C
View Scheme
参考文献
Ramalingan, Chennan; Park, Yong-Tae
Journal of Organic Chemistry, 2007 , vol. 72, # 12 p. 4536 - 4538
反应条件
1: 4-fluoro-benzoic acid With 4-fluorophenylcarboxymagnesium bromide in tetrahydrofuran; diethyl ether
T=0°C;
2: aniline in tetrahydrofuran; diethyl ether
microwave irradiation;
参考文献
Lu, Shui-Yu; Hong, Jinsoo; Pike, Victor W.
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 13 p. 1249 - 1259
反应条件
pyridine; copper diacetate in dichloromethane
31 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Chan, Dominic M. T.
Tetrahedron Letters, 1996 , vol. 37, # 50 p. 9013 - 9016
反应条件
1: AlCl3 / diethyl ether
2: benzene
View Scheme
参考文献
Achmatowicz,O.; Achmatowicz,O.
Roczniki Chemii, 1961 , vol. 35, p. 813 - 820
参考文献
Achmatowicz,O.; Achmatowicz,O.
Roczniki Chemii, 1961 , vol. 35, p. 813 - 820
