1,2-双(4-氟苯基)乙酮合成路线 （共 22 条）
反应条件
titanium tetrachloride; zinc in tetrahydrofuran T=20°C; Inert atmosphereReflux;
参考文献
Lin, Wei; Hu, Ming-Hua; Feng, Xian; Fu, Lei; Cao, Cheng-Pao; Huang, Zhi-Bin; Shi, Da-Qing
Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2238 - 2242
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Cutulic, Sylvain P. Y.; Findlay, Neil J.; Zhou, Sheng-Ze; Chrystal, Ewan J. T.; Murphy, John A.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8713 - 8718
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Cutulic, Sylvain P. Y.; Findlay, Neil J.; Zhou, Sheng-Ze; Chrystal, Ewan J. T.; Murphy, John A.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8713 - 8718
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Cutulic, Sylvain P. Y.; Findlay, Neil J.; Zhou, Sheng-Ze; Chrystal, Ewan J. T.; Murphy, John A.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8713 - 8718
反应条件
1: With sodium hydride in ethanol; benzene T=20°C; Horner-Wadsworth-Emmons type reaction; 18 h; Inert atmosphere; 2: With hydrogenchloride; water in methanol T=20°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 15 p. 4812 - 4819
反应条件
samarium in N,N-dimethyl-formamide T=50°C; 1 h;
参考文献
Liu, Yongjun; Wang, Xiaoxia; Zhang, Yongmin
Synthetic Communications, 2004 , vol. 34, # 21 p. 4009 - 4022
反应条件
1: triethylamine; 1,1'-carbonyldiimidazole / dichloromethane / 6 h / 25 °C 2: diethyl ether / 4 h / 0 - 5 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2843 - 2849
反应条件
tris(trifluoroacetoxy)-λ3-iodane in tetrachloromethane T=23°C; 3 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 62, # 10 p. 3182 - 3186
反应条件
trimethylsilyl iodide in chloroform 3 h;
参考文献
Synthetic Communications, , vol. 16, # 4 p. 377 - 386
反应条件
1: 4-methylfluorobenzene With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: 4-fluorobenzoic acid ethyl ester in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 13 p. 3296 - 3301
