N-(4-氟苯基)苯甲酰胺合成路线 （共 29 条）
反应条件
copper(l) iodide; manganese(II) fluoride; rel-(R,R)-DACH; potassium hydroxide in water
T=100°C; 24 h;
参考文献
Teo, Yong-Chua; Yong, Fui-Fong; Ithnin, Idzham Khalid; Yio, Siew-Hui Trionna; Lin, Zhiyin
European Journal of Organic Chemistry, 2013 , # 3 p. 515 - 524
反应条件
1: N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(4-fluoroaniline) With hydrogenchloride in water; acetone
T=25°C; Hydrolysis; 0.5 h;
2: benzoyl chloride With triethylamine in water; acetone
T=25°C; Acylation; 0.5 h;
参考文献
Tsutsui, Hironori; Ichikawa, Tomoko; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 8 p. 1869 - 1878
反应条件
diethylamino-sulfur trifluoride in dichloromethane
T=0°C; 0.0833333 h;
参考文献
Kikugawa, Yasuo; Matsumoto, Kazuhiro; Mitsui, Kimiyo; Sakamoto, Takeshi
Journal of the Chemical Society, Chemical Communications, 1992 , # 12 p. 921 - 922
反应条件
thionyl chloride in xylene
T=160°C; 10 h;
参考文献
Zhu, ShiZeng; Xu, Bin; Zhang, Jie
Journal of Fluorine Chemistry, 1995 , vol. 74, # 2 p. 203 - 206
反应条件
1: 4-fluoroaniline With n-butyllithium in hexane
T=20°C; 1 h;
2: benzoyl-protected allyl alcohol in hexane
T=20°C; 12 h;
参考文献
Faler, Catherine A.; Joullie, Madeleine M.
Tetrahedron Letters, 2006 , vol. 47, # 40 p. 7229 - 7231
反应条件
bromo-dimethylsulfonium bromide
T=80°C; Beckmann rearrangement; 3 h; Ionic liquid;
参考文献
Yadav, Lal Dhar S.; Garima; Srivastava, Vishnu P.
Tetrahedron Letters, 2010 , vol. 51, # 4 p. 739 - 743
反应条件
nonafluoro-n-butanesulfonyl fluoride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine in acetonitrile
T=80°C; 16 h; Schlenk techniqueInert atmosphere;
参考文献
Li, Haoquan; Neumann, Helfried; Beller, Matthias; Wu, Xiao-Feng
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3183 - 3186
Angew. Chem., 2014 , vol. 126, # 12 p. 3247 - 3250,4
反应条件
sodium hydroxide in water
T=90°C; 20 h;
参考文献
Saxena, Anil K.; Pandey, Suresh K.; Seth; Singh; Dikshit; Carpy
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2025 - 2034
反应条件
1: 100 percent / hydroxylamine hydrochloride; sodium acetate trihydrate / aq. methanol / Heating
2: mercury(II) chloride / acetonitrile / 8 h / 80 °C
View Scheme
参考文献
Ramalingan, Chennan; Park, Yong-Tae
Journal of Organic Chemistry, 2007 , vol. 72, # 12 p. 4536 - 4538
反应条件
PhI(OPiv)2; pyridine hydrogenfluoride in dichloromethane
T=20°C; 12 h; regioselective reaction;
参考文献
Tian, Tian; Zhong, Wen-He; Meng, Shuai; Meng, Xiang-Bao; Li, Zhong-Jun
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 728 - 732
