3-(4-氟苯甲酰基)丙酸合成路线 （共 21 条）
反应条件
aluminium trichloride 4 h;
参考文献
Jefford; Kohmoto; Jaggi; Timari; Rossier; Rudaz; Barbuzzi; Gerard; Burger; Kamalaprija; Mareda; Bernardinelli; Manzanares; Canfield; Fleck; Robinson; Peters
Helvetica Chimica Acta, 1995 , vol. 78, # 3 p. 647 - 662
反应条件
1: 80 percent / 1.) hydrazine, 2.) HCl / ethanol 2: AlCl3 / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1099 - 1101
反应条件
1: 1.) KOH 2: 80 percent / 1.) hydrazine, 2.) HCl / ethanol 3: AlCl3 / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1099 - 1101
反应条件
rat liver microsomes in phosphate buffer T=37°C; Acetoxylation; dealkylation; pH=7.4; 0.5 h; Enzymatic reaction; Enzyme kinetics;
参考文献
Xenobiotica, , vol. 29, # 8 p. 839 - 846
反应条件
sulfuric acid in dichloromethane 8 h; Heating;
参考文献
Jefford; Kohmoto; Jaggi; Timari; Rossier; Rudaz; Barbuzzi; Gerard; Burger; Kamalaprija; Mareda; Bernardinelli; Manzanares; Canfield; Fleck; Robinson; Peters
Helvetica Chimica Acta, 1995 , vol. 78, # 3 p. 647 - 662
反应条件
sulfuric acid in methanol; ethyl acetate
参考文献
CytoMed Incorporated
Patent: US6201016 B1, 2001 ;
参考文献
PanThera Biopharma, LLC
Patent: US2010/286125 A1, 2010 ;
Location in patent: Page/Page column 17 ;
参考文献
BDH Pharmaceuticals Limited
Patent: US3975388 A1, 1976 ;
反应条件
1: Et3N / tetrahydrofuran / 0.5 h / -40 deg C to -20 deg C 2: Ambient temperature 3: 0.5 h / 100 °C 4: ZnCl2 / 0.08 h / 170 °C View Scheme
参考文献
Kozikowski, Alan P.; Ma, Dawei; Romeo, Elena; Auta, James; Papadopoules, Vissilios; et al.
Angewandte Chemie, 1992 , vol. 104, # 8 p. 1092 - 1094
反应条件
1: Et3N / tetrahydrofuran / 0.5 h / -40 deg C to -20 deg C 2: Ambient temperature 3: 0.5 h / 100 °C 4: ZnCl2 / 0.08 h / 170 °C View Scheme
参考文献
Kozikowski, Alan P.; Ma, Dawei; Romeo, Elena; Auta, James; Papadopoules, Vissilios; et al.
Angewandte Chemie, 1992 , vol. 104, # 8 p. 1092 - 1094
