3-(4-氟苯甲酰基)丙酸合成路线 （共 21 条）
反应条件
1: With sodium hydroxide; sodium tetrahydroborate in water T=50°C; 0.25 h; 2: With hydrogenchloride in water T=80°C; 2 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1475368 A1, 2004 ;
Location in patent: Page 45 ;
反应条件
1: NaH / dimethylsulfoxide / 17 h / 100 °C 2: hydrazine / ethanol View Scheme
参考文献
Sircar, Ila; Duell, Bradley L.; Bobowski, George; Bristol, James A.; Evans, Dale B.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1405 - 1413
反应条件
palladium in acetic acid
反应条件
triethylsilane; chloro-trimethyl-silane; anhydrous sodium hydrogen carbonate; triethylamine in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
US2002/58659 A1, ;
US 20020058659 A1
反应条件
1: (reduction) View Scheme
参考文献
Newman,M.S. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2667 - 2669
反应条件
1: Zn-Hg, aq. HCl / toluene / 1 h / Ambient temperature 2: (i) SOCl2, (ii) AlCl3, CS2 View Scheme
参考文献
Adcock,W.; Dewar,M.J.S.
Journal of the American Chemical Society, 1967 , vol. 89, p. 386 - 390
反应条件
sodium hydroxide
8 h; Ambient temperature;
参考文献
Cignarella; Loriga; Pinna; et al.
Farmaco, Edizione Scientifica, 1982 , vol. 37, # 2 p. 133 - 144
反应条件
hydrogenchloride; potassium carbonate
1.) r.t., 14 d, 2.) heating (water bath), 30 min; Yield given. Multistep reaction;
参考文献
Barlocco; Martini; Pinna; Curzu; Sala; Germini
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 8 p. 585 - 594
反应条件
1: 85 percent / Zn amalgam, aq. HCl / toluene / 48 h / Heating
2: 44 percent / borane / tetrahydrofuran; CH2Cl2 / 16 h / Heating
3: 53 percent / PBr3 / CH2Cl2 / 14 h / 60 °C
View Scheme
参考文献
Ganellin, C. Robin; Leurquin, Fabien; Piripitsi, Antonia; Arrang, Jean-Michel; Garbarg, Monique; Ligneau, Xavier; Schunack, Walter; Schwartz, Jean-Charles
Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 395 - 404
反应条件
hydrazine hydrate in ethanol
17 h; Heating;
参考文献
Kane; Huber; Miller; Kehne
Pharmazie, 1992 , vol. 47, # 4 p. 249 - 251
