(4-氟苯甲酰基氨基)-乙酸合成路线 （共 6 条）
反应条件
sodium hydrogencarbonate in dichloromethane; water
参考文献
Hlavica; Niebch
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 1 p. 67 - 74
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Pathuri, Gopal; Agashe, Hrushikesh B.; Awasthi, Vibhudutta; Gali, Hariprasad
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 4 p. 186 - 191
反应条件
sodium hydroxide
T=20°C;
参考文献
Oelschlaeger; Seeling; Radman; Bockhard
Die Pharmazie, 2000 , vol. 55, # 11 p. 825 - 828
反应条件
water; sodium hydroxide in 2-methyl tetrahydrofuran
T=25 - 28°C; 1 h;
参考文献
Chavez, Flavio; Kennedy, Nicole; Rawalpally, Thimma; Williamson, R. Thomas; Cleary, Thomas
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 579 - 584
参考文献
Lang, Lixin; Jagoda, Elaine; Schmall, Bernard; Vuong, Bik-Kee; Adams, H. Richard; Nelson, David L.; Carson, Richard E.; Eckelman, William C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1576 - 1586
反应条件
1.1: sodium hydrogencarbonate / 2-methyl tetrahydrofuran; water / 0.5 h / Cooling
1.2: 3 h / 10 °C / Cooling
2.1: water; sodium hydroxide / 2-methyl tetrahydrofuran / 1 h / 25 - 28 °C
View Scheme
参考文献
Chavez, Flavio; Kennedy, Nicole; Rawalpally, Thimma; Williamson, R. Thomas; Cleary, Thomas
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 579 - 584
