tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.666667 h;

1: triphenylphosphine; copper (I) iodide / bis(triphenylphosphine)palladium dichloride / triethylamine / 20 h / 20 °C 2: 60 percent / triphenylphosphine; Et3N; tetrakis(triphenylphosphine)palladium / toluene / 6 h / 110 °C 3: 71 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C View Scheme

1: 60 percent / triphenylphosphine; Et3N; tetrakis(triphenylphosphine)palladium / toluene / 6 h / 110 °C 2: 71 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C View Scheme