(S)-3-羟基-3-苯基丙酸甲酯合成路线 （共 42 条）
反应条件
1: in dichloromethane; water 0.25 h; Molecular sieve; 2: With 2-pentafluorophenyl-6,17dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine in dichloromethane; water T=20°C; 18 h; Molecular sieve; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 12, # 21 p. 5052 - 5055
反应条件
nickel in ethanol 0.5 h; Ambient temperature;
参考文献
Kang, Suk-Ku; Park, Dong-Chui; Rho, Ho-Sik; Yoon, Seung-Hyun; Shin, Joon-Seob
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 24 p. 3513 - 3514
反应条件
1: 99 percent / H2 / 5percent Pd-C / aq. ethanol / 14 h / 2327.2 Torr 2: 6.5 h / Ambient temperature; lipase PS-30 from Pseudomonas sp. 3: 98 percent / KHCO3 / acetone / 24 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4289 - 4292
反应条件
1: 43 percent / H3BO3, H2 / Raney-Ni / methanol; H2O / 4 h 2: 1.) 0.1 N NaOH / 1.) water, rt; 2.) ether, 0 deg C, 15 min View Scheme
参考文献
Tetrahedron, , vol. 40, # 19 p. 3769 - 3776
反应条件
air; C14H21N; dimethyl zinc; triphenyl-phosphine oxide in tetrahydrofuran; diethyl ether; toluene T=0°C; Reformatsky reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 7-8 p. 975 - 978
反应条件
tetrachlorosilane; (R,R)-N,N'-bis(phosphoramide)-N,N'-Me2-1,5-pentanediamine in dichloromethane T=-78°C; 0.25 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 11 p. 3774 - 3789
反应条件
1: LDA / tetrahydrofuran 2: 6.5 h / Ambient temperature; lipase PS-30 from Pseudomonas sp. 3: 98 percent / KHCO3 / acetone / 24 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4289 - 4292
反应条件
1: 6.5 h / Ambient temperature; lipase PS-30 from Pseudomonas sp. 2: 98 percent / KHCO3 / acetone / 24 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4289 - 4292
反应条件
1: immobilised Candida parapsilosis ATCC 7330 whole cells / H2O; ethanol / 25 °C 2: sodium borohydride 3: 48 percent / immobilised Candida parapsilosis ATCC 7330 whole cells / H2O; methanol / 6 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 21 p. 5133 - 5140
参考文献
Tetrahedron Letters, , vol. 26, # 3 p. 351 - 354
