(S)-3-羟基-3-苯基丙酸甲酯合成路线 （共 42 条）
反应条件
1: 86 percent / CuI, Bu3P, EtAlCl2 / diethyl ether / 2 h / -78 °C 2: LiOH / tetrahydrofuran; H2O / 25 °C 4: 1., HBF4 2., m-chloroperbenzoic acid, KF / 2., DMF View Scheme
参考文献
Helvetica Chimica Acta, , vol. 69, p. 1542 - 1545
反应条件
1: CuI, Bu3P, EtAlCl2 / diethyl ether / 2 h / -120 °C 2: LiOH / tetrahydrofuran; H2O / 25 °C 4: 1., HBF4 2., m-chloroperbenzoic acid, KF / 2., DMF View Scheme
参考文献
Helvetica Chimica Acta, , vol. 69, p. 1542 - 1545
反应条件
1: LiOH / tetrahydrofuran; H2O / 25 °C 3: 1., HBF4 2., m-chloroperbenzoic acid, KF / 2., DMF View Scheme
参考文献
Helvetica Chimica Acta, , vol. 69, p. 1542 - 1545
反应条件
potassium carbonate 14 h; Ambient temperature;
参考文献
Cambie, Richard C.; Coddington, Jan M.; Milbank, Jared B. J.; Pausler, Maria G.; Rustenhoven, Job J.; et al.
Australian Journal of Chemistry, 1993 , vol. 46, # 5 p. 583 - 591
反应条件
1: 10 percent HCl / diethyl ether / 1 h 2: 20 mg / diethyl ether / 0.5 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 51, # 4 p. 471 - 473
反应条件
1: 1.) AD-mix-β 2: 91 percent / Et3N / tetrahydrofuran / 0.5 h / 0 °C 3: 81 percent / Raney nickel / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3513 - 3514
反应条件
1: 91 percent / Et3N / tetrahydrofuran / 0.5 h / 0 °C 2: 81 percent / Raney nickel / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3513 - 3514
反应条件
1: methanol / dichloromethane / 0.5 h / Inert atmosphere 2: hydrogenchloride; acetyl chloride / water / 6 h / 0 °C / Reflux View Scheme
参考文献
Chemical Communications, , vol. 48, # 55 p. 6969 - 6971
反应条件
(-)-N,N-dimethylaminoisoborneol; diethylzinc in tetrahydrofuran T=-20 - 0°C; Reformatsky reaction; 12 h; Product distribution; Further Variations:Reagents;
参考文献
Organic Letters, , vol. 8, # 6 p. 1125 - 1128
反应条件
1: Cu(OH)2; (S, S)-6,6’-bis(1-hydroxy-2,2-dimethylpropyl)-2,2’-bipyridine; acetic acid / water / 12 h / 5 °C 2: sodium peroxoborate tetrahydrate / 4 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 51 p. 12763 - 12766
Angew. Chem., , vol. 124, # 51 p. 12935 - 12938
