(-)-3-(3,4-二甲氧基苯基)-6-[(5,6-二甲氧基苯乙基)甲基氨基]己烷-3-甲腈合成路线 （共 51 条）
反应条件
in acetonitrile
T=50°C; 0.0833333 h;
参考文献
Luurtsema, Gert; Windhorst, Albert D.; Mooijer, Martien P.J.; Herscheid, Jacobus D.M.; Lammertsma, Adriaan A.; Franssen, Eric J.F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 14 p. 1199 - 1207
反应条件
1: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature
2: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
in acetonitrile
T=100°C; 0.0833333 h;
参考文献
Luurtsema, Gert; Windhorst, Albert D.; Mooijer, Martien P.J.; Herscheid, Jacobus D.M.; Lammertsma, Adriaan A.; Franssen, Eric J.F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 14 p. 1199 - 1207
反应条件
1: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
2: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 99 percent / CH2Cl2 / 1 h / 0 °C
2: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature
3: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
1: 1.) NaH / 1.) THF, 45 deg C, 4 h, 2.) THF, from 0 deg C to RT, 14 h
2: 95 percent / NH3, AlMe3 / 1,1,2-trichloro-ethane; toluene / 60 h / Heating
3: 96 percent / Et3N / CH2Cl2 / 2 h / 0 °C
4: 93 percent / NaBH4, tert-butyl alcohol / CH2Cl2 / 70 h / Heating
5: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF, H2O, 0 deg C, 30 min
6: Et3N / CH2Cl2 / 24 h / 0 °C
7: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
1: 1.) NaH / 1.) THF, 45 deg C, 4 h, 2.) THF, for 0 deg C to RT, 14 h
2: 94 percent / NH3, AlMe3 / 1,1,2-trichloro-ethane; toluene / 60 h / Heating
3: 97 percent / Et3N / CH2Cl2 / 2 h / 0 °C
4: 93 percent / NaBH4, tert-butyl alcohol / CH2Cl2 / 70 h / Heating
5: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF, H2O, 0 deg C, 30 min
6: Et3N / CH2Cl2 / 24 h / 0 °C
7: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
1: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF, H2O, 0 deg C, 30 min
2: Et3N / CH2Cl2 / 24 h / 0 °C
3: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
1: 95 percent / NH3, AlMe3 / 1,1,2-trichloro-ethane; toluene / 60 h / Heating
2: 96 percent / Et3N / CH2Cl2 / 2 h / 0 °C
3: 93 percent / NaBH4, tert-butyl alcohol / CH2Cl2 / 70 h / Heating
4: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF, H2O, 0 deg C, 30 min
5: Et3N / CH2Cl2 / 24 h / 0 °C
6: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
1: 94 percent / NH3, AlMe3 / 1,1,2-trichloro-ethane; toluene / 60 h / Heating
2: 97 percent / Et3N / CH2Cl2 / 2 h / 0 °C
3: 93 percent / NaBH4, tert-butyl alcohol / CH2Cl2 / 70 h / Heating
4: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H2O2 / 1.) THF, 0 deg C, 1 h, 2.) THF, H2O, 0 deg C, 30 min
5: Et3N / CH2Cl2 / 24 h / 0 °C
6: Et3N / tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
