(-)-3-(3,4-二甲氧基苯基)-6-[(5,6-二甲氧基苯乙基)甲基氨基]己烷-3-甲腈合成路线 （共 51 条）
反应条件
1: 89 percent / DIBAL-H / toluene / 1 h / 20 °C
2: 92 percent / pyridine
3: 85 percent / dimethylsulfoxide / 2 h / 80 °C
4: 81 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
5: 98 percent / diethyl ether
6: 84 percent / DIBAL-H / toluene / 1 h / 20 °C
7: 98 percent / pyridine
8: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
9: hydroxylamine hydrochloride; sodium acetate / ethanol
10: 1.52 g / sodium acetate / acetic anhydride / Heating
11: potassium hydroxide / methanol / 2 h / Heating
12: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
13: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 91 percent / DIBAL-H / toluene / 1 h / 20 °C
2: 90 percent / pyridine
3: 84 percent / dimethylsulfoxide / 2 h / 80 °C
4: 79 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
5: 97 percent / diethyl ether
6: 80 percent / DIBAL-H / toluene / 1 h / 20 °C
7: 98 percent / pyridine
8: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
9: hydroxylamine hydrochloride; sodium acetate / ethanol
10: 1.19 g / sodium acetate / acetic anhydride / Heating
11: potassium hydroxide / methanol / 2 h / Heating
12: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
13: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 81 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
2: 98 percent / diethyl ether
3: 84 percent / DIBAL-H / toluene / 1 h / 20 °C
4: 98 percent / pyridine
5: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
6: hydroxylamine hydrochloride; sodium acetate / ethanol
7: 1.52 g / sodium acetate / acetic anhydride / Heating
8: potassium hydroxide / methanol / 2 h / Heating
9: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
10: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 79 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
2: 97 percent / diethyl ether
3: 80 percent / DIBAL-H / toluene / 1 h / 20 °C
4: 98 percent / pyridine
5: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
6: hydroxylamine hydrochloride; sodium acetate / ethanol
7: 1.19 g / sodium acetate / acetic anhydride / Heating
8: potassium hydroxide / methanol / 2 h / Heating
9: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
10: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 98 percent / pyridine
2: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
3: hydroxylamine hydrochloride; sodium acetate / ethanol
4: 1.52 g / sodium acetate / acetic anhydride / Heating
5: potassium hydroxide / methanol / 2 h / Heating
6: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
7: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 98 percent / pyridine
2: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
3: hydroxylamine hydrochloride; sodium acetate / ethanol
4: 1.19 g / sodium acetate / acetic anhydride / Heating
5: potassium hydroxide / methanol / 2 h / Heating
6: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
7: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 84 percent / DIBAL-H / toluene / 1 h / 20 °C
2: 98 percent / pyridine
3: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
4: hydroxylamine hydrochloride; sodium acetate / ethanol
5: 1.52 g / sodium acetate / acetic anhydride / Heating
6: potassium hydroxide / methanol / 2 h / Heating
7: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
8: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 80 percent / DIBAL-H / toluene / 1 h / 20 °C
2: 98 percent / pyridine
3: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
4: hydroxylamine hydrochloride; sodium acetate / ethanol
5: 1.19 g / sodium acetate / acetic anhydride / Heating
6: potassium hydroxide / methanol / 2 h / Heating
7: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
8: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol
2: 1.52 g / sodium acetate / acetic anhydride / Heating
3: potassium hydroxide / methanol / 2 h / Heating
4: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
5: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol
2: 1.19 g / sodium acetate / acetic anhydride / Heating
3: potassium hydroxide / methanol / 2 h / Heating
4: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
5: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
