(-)-3-(3,4-二甲氧基苯基)-6-[(5,6-二甲氧基苯乙基)甲基氨基]己烷-3-甲腈合成路线 （共 51 条）
反应条件
1: 98 percent / diethyl ether
2: 84 percent / DIBAL-H / toluene / 1 h / 20 °C
3: 98 percent / pyridine
4: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
5: hydroxylamine hydrochloride; sodium acetate / ethanol
6: 1.52 g / sodium acetate / acetic anhydride / Heating
7: potassium hydroxide / methanol / 2 h / Heating
8: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
9: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 97 percent / diethyl ether
2: 80 percent / DIBAL-H / toluene / 1 h / 20 °C
3: 98 percent / pyridine
4: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
5: hydroxylamine hydrochloride; sodium acetate / ethanol
6: 1.19 g / sodium acetate / acetic anhydride / Heating
7: potassium hydroxide / methanol / 2 h / Heating
8: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
9: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: potassium hydroxide / methanol / 2 h / Heating
2: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
3: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
2: hydroxylamine hydrochloride; sodium acetate / ethanol
3: 1.52 g / sodium acetate / acetic anhydride / Heating
4: potassium hydroxide / methanol / 2 h / Heating
5: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
6: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
2: hydroxylamine hydrochloride; sodium acetate / ethanol
3: 1.19 g / sodium acetate / acetic anhydride / Heating
4: potassium hydroxide / methanol / 2 h / Heating
5: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
6: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 85 percent / dimethylsulfoxide / 2 h / 80 °C
2: 81 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
3: 98 percent / diethyl ether
4: 84 percent / DIBAL-H / toluene / 1 h / 20 °C
5: 98 percent / pyridine
6: 68 percent / ozone; triphenylphosphane / CH2Cl2; methanol
7: hydroxylamine hydrochloride; sodium acetate / ethanol
8: 1.52 g / sodium acetate / acetic anhydride / Heating
9: potassium hydroxide / methanol / 2 h / Heating
10: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
11: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: 84 percent / dimethylsulfoxide / 2 h / 80 °C
2: 79 percent / 20percent KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating
3: 97 percent / diethyl ether
4: 80 percent / DIBAL-H / toluene / 1 h / 20 °C
5: 98 percent / pyridine
6: 69 percent / ozone; triphenylphosphane / CH2Cl2; methanol
7: hydroxylamine hydrochloride; sodium acetate / ethanol
8: 1.19 g / sodium acetate / acetic anhydride / Heating
9: potassium hydroxide / methanol / 2 h / Heating
10: 95 percent / triphenylphosphane / CCl4 / 2 h / Heating
11: 91 percent / 1 h / 130 °C
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
1: (i) NaNH2, Fe(NO3)3, liq. NH3, (ii) /BRN= 1098244/
2: (i) NaNH2, Fe(NO3)3, liq. NH3, (ii) /BRN= 605308/
3: aq. KOH / dimethylsulfoxide / 48 h / 90 °C
4: (i) PCl5, Et2O, (ii) liq. NH3, bis-(2,3-dimethyl-propyl)-borane, THF, (iii) aq. H2O2
5: 2,2,2-trichloro-<1,3,2>benzodioxaphospholane / 100 °C
6: 4 h / 130 °C
View Scheme
参考文献
Ramuz
Helvetica chimica acta, 1975 , vol. 58, # 7 p. 2050 - 2060
反应条件
1: (i) NaNH2, Fe(NO3)3, liq. NH3, (ii) /BRN= 605308/
2: aq. KOH / dimethylsulfoxide / 48 h / 90 °C
3: (i) PCl5, Et2O, (ii) liq. NH3, bis-(2,3-dimethyl-propyl)-borane, THF, (iii) aq. H2O2
4: 2,2,2-trichloro-<1,3,2>benzodioxaphospholane / 100 °C
5: 4 h / 130 °C
View Scheme
参考文献
Ramuz
Helvetica chimica acta, 1975 , vol. 58, # 7 p. 2050 - 2060
反应条件
1: aq. KOH / dimethylsulfoxide / 48 h / 90 °C
2: (i) PCl5, Et2O, (ii) liq. NH3, bis-(2,3-dimethyl-propyl)-borane, THF, (iii) aq. H2O2
3: 2,2,2-trichloro-<1,3,2>benzodioxaphospholane / 100 °C
4: 4 h / 130 °C
View Scheme
参考文献
Ramuz
Helvetica chimica acta, 1975 , vol. 58, # 7 p. 2050 - 2060
