N1-(4-丁基苯基)乙酰胺合成路线 （共 14 条）
反应条件
1: glacial acetic acid; nitric acid / -5 - 5 °C
2: alcoholic KOH-solution / Hydrolysis
3: copper powder / Diazotization.Verkochen mit Alkohol
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参考文献
Reilly; Hickinbottom
Journal of the Chemical Society, 1920 , vol. 117, p. 133
反应条件
1: 70 percent / fuming nitric acid, acetic anhydride / acetic acid / 6 h / -15 °C
2: 76 percent / aq. potassium hydroxide / ethanol; H2O / 1 h / Heating
3: 75 percent / H2 / 10percent Pd/C / methanol / 12 h / 760 Torr / Ambient temperature
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参考文献
Reilly; Hickinbottom
Journal of the Chemical Society, 1920 , vol. 117, p. 133
反应条件
(i) K2CO3, CuI, (ii) KOH, EtOH; Multistep reaction;
参考文献
Takada,A.; Nishimura,H.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, p. 1 - 8
反应条件
1: glacial acetic acid; nitric acid / -5 - 5 °C
2: alcoholic KOH-solution / Hydrolysis
3: copper powder / Diazotization.Verkochen mit Alkohol
4: tin; hydrochloric acid
View Scheme
参考文献
Reilly; Hickinbottom
Journal of the Chemical Society, 1920 , vol. 117, p. 133
