2,3-二氢-1,4-苯并二英-2-碳酰氯合成路线 （共 10 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 4 h;
参考文献
FENG, Yangbo; LOGRASSO, Philip; BANNISTER, Thomas; SCHROETER, Thomas; FANG, Xingang; YIN, Yan; CHEN, Yen Ting; SESSIONS, Hampton; CHOWDHURY, Sarwat; LUO, Jun-Li; VOJKOVSKY, Tomas
Patent: WO2010/56758 A1, 2010 ;
Location in patent: Page/Page column 50-51 ;
WO 2010/056758 A1
反应条件
1: lithium hydroxide hydrate; water / tetrahydrofuran / 4 h / 20 °C 2: thionyl chloride / 1 h / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 7 p. 1766 - 1770
反应条件
sodium hydroxide; thionyl chloride
参考文献
Farmaco, , vol. 44, # 11 p. 1109 - 1117
反应条件
hydrogenchloride; sodium hydroxide; sodium acetate in water; ethyl acetate; acetone
参考文献
Pfizer Inc.
Patent: US4188390 A1, 1980 ;
反应条件
hydrogenchloride; sodium hydroxide; potassium permanganate; thionyl chloride; sodium acetate in aqueous potassium hydroxide; water; ethyl acetate; acetone
参考文献
Pfizer Inc.
Patent: US4287341 A1, 1981 ;
反应条件
hydrogenchloride in methanol; ethyl acetate 0.5 h;
参考文献
Campbell; Davey; Hardstone; Lewis; Palmer
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 49 - 57
反应条件
pyridine in 1,4-dioxane T=70°C;
参考文献
Vartanyan; Sargsyan; Avakyan; Markaryan; Asatryan
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 7 p. 972 - 976
Zh. Org. Khim., 2012 , vol. 48, # 7 p. 976 - 979,4
反应条件
1: H2O; CHCl3 / 2 h / 20 °C
2: LiAlH4 / tetrahydrofuran / 12 h / Heating
3: 6N HCl / H2O / 12 h / Ambient temperature
4: 9 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 8 h / Ambient temperature
View Scheme
参考文献
Mauleon; Antunez; Rosell
Farmaco, 1989 , vol. 44, # 11 p. 1109 - 1117
反应条件
1: H2O; CHCl3 / 2 h / 20 °C
2: LiAlH4 / tetrahydrofuran / 12 h / Heating
3: 6N HCl / H2O / 12 h / Ambient temperature
4: 9 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 8 h / Ambient temperature
5: LiAlH4 / tetrahydrofuran; diethyl ether / 3 h / Heating
View Scheme
参考文献
Mauleon; Antunez; Rosell
Farmaco, 1989 , vol. 44, # 11 p. 1109 - 1117
反应条件
1: H2O; CHCl3 / 2 h / 20 °C
2: LiAlH4 / tetrahydrofuran / 12 h / Heating
3: 6N HCl / H2O / 12 h / Ambient temperature
View Scheme
参考文献
Mauleon; Antunez; Rosell
Farmaco, 1989 , vol. 44, # 11 p. 1109 - 1117
