Alpha-对甲苯磺酰基苄基异腈合成路线 （共 9 条）
反应条件
triethylamine; trichlorophosphate in tetrahydrofuran T=0°C; Yield given;
参考文献
Tetrahedron Letters, , vol. 37, # 45 p. 8113 - 8116
反应条件
1: 94 percent / TMSCl / toluene; acetonitrile / 5 h / 50 °C 2: POCl3, Et3N / tetrahydrofuran / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 45 p. 8113 - 8116
反应条件
1: 94 percent / TMSCl / toluene; acetonitrile / 5 h / 50 °C 2: POCl3, Et3N / tetrahydrofuran / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 45 p. 8113 - 8116
反应条件
(i) nBuLi, (ii) /BRN= 2208423/; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 42, # 7 p. 1153 - 1159
反应条件
1: 17 percent / NaH / dimethylsulfoxide; diethyl ether / 0.75 h / Heating 2: 90 percent / conc. aq. HCl / CH2Cl2; diethyl ether / 0.5 h / Ambient temperature View Scheme
参考文献
Leusen, Albert M. van; Oosterwijk, Roelof; Echten, Erik van; Leusen, Daan van
Recueil des Travaux Chimiques des Pays-Bas, 1985 , vol. 104, p. 50 - 53
反应条件
tetra-(n-butyl)ammonium iodide in water; acetonitrile Ambient temperatureelectrolysis;
参考文献
Pharmazie, , vol. 54, # 6 p. 412 - 417
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide
0.5 h; Ambient temperature;
参考文献
Di Santo; Costi; Massa; Artico
Synthetic Communications, 1995 , vol. 25, # 6 p. 795 - 802
反应条件
n-butyllithium; lithium bromide
1.) THF, n-hexane, -45 deg C, 0.5 h, 2.) THF, n-hexane, RT, 8 d; Yield given. Multistep reaction;
参考文献
Di Santo; Costi; Massa; Artico
Synthetic Communications, 1995 , vol. 25, # 6 p. 795 - 802
反应条件
1: glycolaldehyde dimer; methylamine in tetrahydrofuran
1.25 h;
2: phenyl-TosMIC in tetrahydrofuran
T=30°C; 1.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/13141 A1, 2004 ;
Location in patent: Page 83-84 ;
WO 2004/013141 A1
