3-(4-氟-苯基)-1-苯基-1H-吡唑-4-甲醛合成路线 （共 12 条）
反应条件
trichlorophosphate T=70 - 80°C; 5 h;
参考文献
Desai; Joshi; Rajpara; Vaghani; Satodiya
Journal of Fluorine Chemistry, 2012 , vol. 142, p. 67 - 78
反应条件
in N,N-dimethyl-formamide T=70 - 80°C; Vilsmeier-Haack Formylation; 6 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 10 p. 2772 - 2777
反应条件
2: trichlorophosphate View Scheme
参考文献
Synthetic Communications, , vol. 41, # 1 p. 136 - 146
反应条件
2: trichlorophosphate View Scheme
参考文献
Synthetic Communications, , vol. 41, # 1 p. 136 - 146
反应条件
1: 1-fluoro-4-acetyl-benzene; phenylhydrazine 2: N,N-dimethyl-formamide With trichlorophosphate Vilsmeier-Haack reaction;
参考文献
Yu, Zhi-Hua; Shi, De-Qing
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 8 p. 1746 - 1752
反应条件
1: sodium acetate / ethanol / 3 h / 50 - 60 °C 2: trichlorophosphate / 5 h / 50 - 60 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 68, p. 1 - 9
反应条件
piperidine in pyridine T=95 - 100°C;
参考文献
Bernard; Hulley; Molenda; Stochla; Wrzeciono
Die Pharmazie, 1986 , vol. 41, # 8 p. 560 - 562
反应条件
pyridine 0.0833333 h; microwave irradiation;
参考文献
Chornous, Vitaliy O.; Bratenko, Mykhaylo K.; Vovk, Mykhaylo V.
Synthetic Communications, 2004 , vol. 34, # 1 p. 79 - 83
反应条件
1: 71.1 percent / piperidine 2: 74.8 percent / NaOH / methanol; H2O / 2 h / Heating 3: pyridine / 0.5 h / 100 °C View Scheme
参考文献
Bernard; Hulley; Molenda; Stochla; Wrzeciono
Die Pharmazie, 1986 , vol. 41, # 8 p. 560 - 562
反应条件
sodium tetrahydroborate in ethanol
1 h;
参考文献
Bratenko; Chornous; Vovk
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 3 p. 411 - 414
