1: hexadecan-1-ol With diisobutylaluminium hydride in hexane; dichloromethane
1 h; Cooling with ice;
2: (S)-(-)-glycidol in hexane; dichloromethane
T=20°C; 72 h;
3: With water; Sodium potassium tartrate in hexane; dichloromethane
0.5 h;
参考文献
North, E. Jeffrey; Osborne, Daniel A.; Bridson, Peter K.; Baker, Daniel L.; Parrill, Abby L.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 9 p. 3433 - 3442
1: hexadecan-1-ol With triethylamine; trichlorophosphate in tetrahydrofuran
T=0°C; 0.0833333 h; C16H33OH was added during 30 min;
2: ethanolamine With hydrogenchloride; triethylamine
T=20°C; 3 h; Adding at 0 degree;C during 60 minHeating at 40 degree;C and 10 percent HCl was added, 2 h;
参考文献
Bracco International B.V.
Patent: US6342598 B1, 2002 ;
Location in patent: Page column 35-36 ;
