3-(4-氯苯基)-1-苯基-1H-吡唑-4-甲醛合成路线 （共 20 条）
反应条件
trichlorophosphate
T=0 - 25°C; Vilsmeier-Haack Formylation; 24 h;
参考文献
Paul, Nidhin; Muthusubramanian, Shanmugam
Helvetica Chimica Acta, 2013 , vol. 96, # 3 p. 452 - 457
反应条件
1.1: 25 °C
1.2: dimethylformamide / 16 h / 20 °C
2.1: aq. Na2CO3
View Scheme
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
trichlorophosphate
1.) 30 min, room temp.; 2.) 2 h, 75 deg C; Yield given. Multistep reaction;
参考文献
Rainer; Krueger; Klemm
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 4 p. 649 - 655
反应条件
pyridine; potassium permanganate in water
T=20 - 22°C;
参考文献
Bratenko; Chornous; Vovk
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 4 p. 552 - 555
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
1.75 h;
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
1: 99 percent / 97percent NaBH4 / aq. ethanol / 0.5 h / 35 - 40 °C
2: 100 percent / SOCl2 / benzene / 2.5 h / Heating
3: 98 percent / dimethylsulfoxide / 1 h / 40 - 45 °C
4: 97 percent / 62percent H2SO4 / 2.5 h / 125 °C
View Scheme
参考文献
Rainer; Krueger; Klemm
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 4 p. 649 - 655
反应条件
1: 99 percent / 97percent NaBH4 / aq. ethanol / 0.5 h / 35 - 40 °C
2: 100 percent / SOCl2 / benzene / 2.5 h / Heating
3: 98 percent / dimethylsulfoxide / 1 h / 40 - 45 °C
View Scheme
参考文献
Rainer; Krueger; Klemm
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 4 p. 649 - 655
反应条件
piperidine in pyridine
T=95 - 100°C;
参考文献
Bernard; Hulley; Molenda; Stochla; Wrzeciono
Die Pharmazie, 1986 , vol. 41, # 8 p. 560 - 562
反应条件
pyridine
0.0833333 h; microwave irradiation;
参考文献
Chornous, Vitaliy O.; Bratenko, Mykhaylo K.; Vovk, Mykhaylo V.
Synthetic Communications, 2004 , vol. 34, # 1 p. 79 - 83
反应条件
1: 80 percent / piperidine
2: 76.6 percent / NaOH / methanol; H2O / 2 h / Heating
3: pyridine / 0.5 h / 100 °C
View Scheme
参考文献
Bernard; Hulley; Molenda; Stochla; Wrzeciono
Die Pharmazie, 1986 , vol. 41, # 8 p. 560 - 562
