利伐沙班合成路线

参考文献

LABORATORIOS LESVI, S. L.; VISHNU NEWADKAR, Ravindranath; CHANGDEO GAIKWAD, Avinash; MADHUKAR HARAD, Ajay; DALMASES BARJOAN, Pere
Patent: WO2013/53739 A1, 2013 ;
Location in patent: Page/Page column 34 ;

898543-06-14-[4-[(5S)-5-(氨基甲基)-2-氧代-3-恶唑烷基]苯基]-3-吗啉酮盐酸盐+

1450877-56-1

366789-02-8利伐沙班

参考文献

MEGAFINE PHARMA (P) LTD; MATHAD Vijayavitthal Thippannachar; PATIL NILESH SUDHIR, Nilesh; NIPHADE NAVNATH CHINTAMAN, Navnath; MALI ANIL CHATURLAL, Anil; BODAKE MAHENDRA BHAGIRATH, Mahendra; IPPAR SHARAD SUBHASH, Sharad; TALLA RAJESH, Rajesh
Patent: WO2013/121436 A2, 2013 ;
Location in patent: Page/Page column 31 ;

42518-98-95-氯-2-酰氯噻吩+

1251952-62-1

366789-02-8利伐沙班

参考文献

ZENTIVA, K.S.; HALAMA Ales; KRULIS Radim; DAMMER, Ondrej; KALASEK, Stanislav
Patent: WO2013/120465 A1, 2013 ;
Location in patent: Page/Page column 37; 38 ;

366789-02-8利伐沙班

参考文献

WO2012/159992 A1, ;

Page/Page column 21 ;

42518-98-95-氯-2-酰氯噻吩+

1430407-74-1

366789-02-8利伐沙班

参考文献

LABORATORIOS LESVI, S. L.; VISHNU NEWADKAR, Ravindranath; CHANGDEO GAIKWAD, Avinash; MADHUKAR HARAD, Ajay; DALMASES BARJOAN, Pere
Patent: WO2013/53739 A1, 2013 ;
Location in patent: Page/Page column 35 ;

1313613-23-8

366789-02-8利伐沙班

参考文献

ENANTIA, S.L.; RAFECAS JANE, Llorenc; COMELY, Alexander Christian; FERRALI, Alessandro; AMELA CORTES, Celia; PASTO AGUILA, Mireia
Patent: WO2011/80341 A1, 2011 ;
Location in patent: Page/Page column 24 ;

1313613-18-1+

1325210-61-4

366789-02-8利伐沙班

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SANDOZ AG; STURM, Hubert; DE SOUZA, Dominic; KNEPPER, Kerstin; ALBERT, Martin
Patent: WO2011/98501 A1, 2011 ;
Location in patent: Page/Page column 30; 31 ;

799012-78-5+

1325210-64-74-(4-异氰酰苯基)吗啉-3-酮

366789-02-8利伐沙班

参考文献

SANDOZ AG; STURM, Hubert; DE SOUZA, Dominic; KNEPPER, Kerstin; ALBERT, Martin
Patent: WO2011/98501 A1, 2011 ;
Location in patent: Page/Page column 29 ;

24065-33-62-氯噻吩-5-甲酸+

898543-06-14-[4-[(5S)-5-(氨基甲基)-2-氧代-3-恶唑烷基]苯基]-3-吗啉酮盐酸盐

366789-02-8利伐沙班

参考文献

EGIS GYOGYSZERGYAR NYILVANOSAN MUeKOeDOe RESZVENY-TARSASAG; SIPOS, Eva; KOVANYINE LAX, Gyoergyi; HAVASI, Balazs; VOLK, Balazs; KRASZNAI, Gyoergy; RUZSICS, Gyoergy; BARKOCZY, Jozsef; TOTHNE LAURITZ, Maria; LUKACS, Gyula; BOZA, Andras; HEGEDUeS, Laszlo Jozsef; TABORINE TOTH, Maria Julia; PECSI, Eva
Patent: WO2012/153155 A1, 2012 ;
Location in patent: Page/Page column 56 ;

1313613-21-6

366789-02-8利伐沙班

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WO2011/80341 A1, ;

Page/Page column 20; 21 ;