3,4-二氨基苯甲酸甲酯合成路线 （共 20 条）
反应条件
1: methanol 2: ethanolic NaOH View Scheme
参考文献
Thomas; Tyler
Journal of the Chemical Society, 1957 , p. 2197,2199
反应条件
in methanol; water T=50°C; 1 h;
参考文献
Frei, Reto; Breitbach, Anthony S.; Blackwell, Helen E.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 21 p. 5226 - 5229
反应条件
in tetrahydrofuran T=0°C; 16 h;
参考文献
WO2009/134750 A1, ;
Page/Page column 139 ;
反应条件
bromobenzene
Heating;
参考文献
Dannley,R.L.; Wagner,P.L.
Journal of Organic Chemistry, 1961 , vol. 26, p. 3995 - 3997
反应条件
1: in water; acetonitrile
T=20°C;
2: With ammonia in water; ethyl acetate; acetonitrile
3: With hydrogenchloride in water
Reflux;
参考文献
PFIZER INC.
Patent: US2012/270893 A1, 2012 ;
Location in patent: Page/Page column 27 ;
反应条件
1: 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium*PF6; N,N-diisopropylethylamine / dimethylformamide / 12 h / 60 °C
2: acetic acid / 12 h / 90 °C
3: 0.6 g / aq. NaOH / dioxane / 12 h / 20 - 60 °C
View Scheme
参考文献
Viger, Anne; Dervan, Peter B.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8539 - 8549
反应条件
1.5 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/67529 A1, 2004 ;
Location in patent: Page 191 ;
WO 2004/067529 A1
反应条件
triethylamine in toluene
参考文献
Dannley,R.L.; Grava,A.
Canadian Journal of Chemistry, 1965 , vol. 43, p. 3377 - 3386
反应条件
methanesulfonic acid; hydrogen; [Ru(acac)3]; 1,1,1-tris (diphenylphosphinomethyl)ethane in tetrahydrofuran
T=140°C; AutoclaveInert atmosphere;
参考文献
Li, Yuehui; Sorribes, Ivan; Yan, Tao; Junge, Kathrin; Beller, Matthias
Angewandte Chemie - International Edition, 2013 , vol. 52, # 46 p. 12156 - 12160
Angew. Chem., 2013 , vol. 125, # 46 p. 12378 - 12382,5
反应条件
pyridine; 4-pyrrolidin-1-ylpyridine in acetonitrile
72 h; Inert atmosphereReflux;
参考文献
UNIVERSITY OF SUNDERLAND; TODD, Adam; ANDERSON, Rosaleen Joy; SMALL, David Antony Philip; GROUNDWATER, Paul William; BENTON, Matthew Richard
Patent: WO2014/96864 A1, 2014 ;
Location in patent: Paragraph 00177 ;
