1: ortho-difluorobenzene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran 2: 1-iodo-propane With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 11 p. 2693 - 2699
1.1: sulfuric acid; nitric acid / 16 h / 20 - 100 °C 2.1: sodium hydride / ethylene glycol dimethyl ether; mineral oil / 1 h / 20 °C / |Inert atmosphere 2.2: 20 °C / |Inert atmosphere View Scheme
参考文献
De Hatten, Xavier; Asil, Demet; Friend, Richard H.; Nitschke, Jonathan R.
Journal of the American Chemical Society, 2012 , vol. 134, # 46 p. 19170 - 19178
