反应条件
1.1: nitric acid / dichloromethane / 1 h / 0 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 - 60 °C 3.1: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2844.39 Torr 4.1: sodium nitrite / water / 1 h / -5 - 0 °C 4.2: 2 h / 0 - 50 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong
Patent: WO2013/28474 A1, 2013 ;