3-氯-4-氟苯胺合成路线

参考文献

Hildebrand, Catherine; Sandoli, Daniele; Focher, Federico; Gambino, Joseph; Ciarrocchi, Giovanni; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 203 - 206

4441-30-94-(3-羟丙基)吗啉+

367-21-53-氯-4-氟苯胺+

162012-69-37-氟-6-硝基-4-羟基喹唑啉

267243-64-1N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺

参考文献

Barth, Hubert; Bridges, Alexander James; Heemstra, Ronald J.; Horne, Nicole Marcia; Hughes, Robert Craig; Jacks, Thomas Elliott; McNamara, Dennis Joseph; Schneider, Simon; Steiner, Klaus; Toogood, Peter Laurence; Winters, Roy Thomas
Patent: US2004/158065 A1, 2004 ;
Location in patent: Page 20 ;

4441-30-94-(3-羟丙基)吗啉+

367-21-53-氯-4-氟苯胺+

865-47-4叔丁醇钾+

162012-69-37-氟-6-硝基-4-羟基喹唑啉

267243-64-1N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺

参考文献

Barth, Hubert; Steiner, Klaus; Schneider, Simon
Patent: US2003/50313 A1, 2003 ;

367-21-53-氯-4-氟苯胺

267243-64-1N-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)-6-硝基喹唑啉-4-胺

参考文献

Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397

367-21-53-氯-4-氟苯胺+

87-13-8乙氧基甲叉丙二酸二乙酯

70458-93-47-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯

参考文献

Saxena, Anil K.; Roy, Kuldeep K.; Singh, Supriya; Vishnoi; Kumar, Anil; Kashyap, Vivek Kr.; Kremer, Laurent; Srivastava, Ranjana; Srivastava, Brahm S.
International Journal of Antimicrobial Agents, 2013 , vol. 42, # 1 p. 27 - 35

70458-93-47-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯

参考文献

American Cyanamid Company
Patent: US4940710 A1, 1990 ;

367-21-53-氯-4-氟苯胺+

70032-30-3二乙基[[(3-氯-4-氟苯基)氨基]亚甲基]丙二酸酯+

87-13-8乙氧基甲叉丙二酸二乙酯

70458-93-47-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯

参考文献

Laboratorie Roger Bellon; Dainippon Pharmaceutical
Patent: US4292317 A1, 1981 ;
US 4292317 A

367-21-53-氯-4-氟苯胺

70458-93-47-氯-6-氟-4-4羟基-3-喹啉甲酸乙酯

参考文献

Hiltensperger, Georg; Jones, Nicola G.; Niedermeier, Sabine; Stich, August; Kaiser, Marcel; Jung, Jamin; Puhl, Sebastian; Damme, Alexander; Braunschweig, Holger; Meinel, Lorenz; Engstler, Markus; Holzgrabe, Ulrike
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2538 - 2548

367-21-53-氯-4-氟苯胺

70458-94-57-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯

参考文献

Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363

367-21-53-氯-4-氟苯胺+

87-13-8乙氧基甲叉丙二酸二乙酯

70458-94-57-氯-1-乙基-6-氟-1,4-二氢-4-氧代喹啉-3-羧酸乙酯

参考文献

Vymed Corporation; SHETTY, B. Vithal
Patent: US2014/73631 A1, 2014 ;