3-氯-4-氟苯胺合成路线

参考文献

Chandregowda, Venkateshappa; Rao, Gudapati Venkateswara; Reddy, Goukanapalli Chandrasekara
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 813 - 816

367-21-53-氯-4-氟苯胺

184475-35-2吉非替尼

参考文献

CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Seung Uk; WOO, Dae Koo; KANG, Sung Kwon; KIM, Dong Jin; PARK, Dae Jong
Patent: WO2013/180403 A1, 2013 ;

184475-35-2吉非替尼

参考文献

NATCO PHARMA LIMITED; JYOTHI PRASAD, Ramanadham; PULLA REDDY, Muddasani; NAGESHWARA RAO, Bollepalli; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2005/70909 A1, 2005 ;
Location in patent: Page/Page column 28; 30 ;

367-21-53-氯-4-氟苯胺

2613-23-23-氯-4-氟苯酚

参考文献

Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97

367-21-53-氯-4-氟苯胺+

162012-70-64-氯-7-氟-6-硝基喹唑啉

162012-67-1N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺

参考文献

ZHANG, Qiang; ZHU, Hongwen
Patent: WO2011/84796 A2, 2011 ;
Location in patent: Page/Page column 55-56 ;

367-21-53-氯-4-氟苯胺

162012-67-1N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺

参考文献

XUANZHU PHARMA CO., LTD.; Huang, Zhenhua; Dong, Yanyan
Patent: US2013/184297 A1, 2013 ;
Location in patent: Paragraph 0065; 0066 ;

367-21-53-氯-4-氟苯胺

257933-82-7培利替尼

参考文献

Wissner, Allan; Overbeek, Elsebe; Reich, Marvin F.; Floyd, M. Brawner; Johnson, Bernard D.; Mamuya, Nellie; Rosfjord, Edward C.; Discafani, Carolyn; Davis, Rachel; Shi, Xiaoqing; Rabindran, Sridhar K.; Gruber, Brian C.; Ye, Fei; Hallett, William A.; Nilakantan, Ramaswamy; Shen, Ru; Wang, Yu-Fen; Greenberger, Lee M.; Tsou, Hwei-Ru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 49 - 63

169674-00-46-氯-5-氟-1H-吲哚-2-甲酸乙酯

参考文献

US5494928 A1, ;
US 5494928 A

367-21-53-氯-4-氟苯胺+

24424-99-5二碳酸二叔丁酯

119951-96-1(3-氯-4-氟-苯基)-氨基甲酸叔丁酯

参考文献

Sarkar, Anirban; Roy, Sudipta Raha; Parikh, Naisargee; Chakraborti, Asit K.
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7132 - 7140

367-21-53-氯-4-氟苯胺

116162-74-4

参考文献

Shindikar, Anand V.; Viswanathan
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1803 - 1806