反应条件
1: 1.) aluminum chloride / 1.) 50 deg C, 1 h, 2.) 80 deg C, 22 h
2: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C
3: thionyl chloride / 4 h / 80 °C
4: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h
5: 1.) acetic anhydride / 1.) 125 deg C, 2 h, 2.) methylene chloride, 45 min
6: 77 percent / sodium hydride / tetrahydrofuran / 13 h / 50 °C
7: 98 percent / 6 N hydrochloric acid / trifluoroacetic acid / 48 h / 70 °C
View Scheme
参考文献
Chu, Daniel T. W.; Nordeen, Carl W.; Hardy, Dwight J.; Swanson, Robert N.; Giardina, William J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 168 - 174
