反应条件
1: 91 percent / Br2 / acetic acid / 0.25 h / Ambient temperature 2: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h 3: 77 percent / N,N-dimethyl-acetamide / 4 h / Heating 4: 71 percent / 90 percent formic acid / Raney nickel alloy / 2 h / Heating 5: 66 percent / pyridine, piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h 6: 97 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
