3,5-二(三氟甲基)-1,2-苯二胺合成路线 （共 6 条）
反应条件
stannous chloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; chloroform
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
hydrogenchloride; ethanol; tin(ll) chloride
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating 4: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: sulfuric acid; nitric acid / water / 0 - 20 °C 2: water; sodium hydroxide / methanol / 2 h / 110 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C View Scheme
参考文献
Lee, Myungmo; Zhang, Lei; Park, Yohan; Park, Hyeung-Geun
Tetrahedron, 2012 , vol. 68, # 5 p. 1452 - 1459
反应条件
1: 3 h / 20 °C 2: sulfuric acid; nitric acid / water / 0 - 20 °C 3: water; sodium hydroxide / methanol / 2 h / 110 °C 4: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C View Scheme
参考文献
Lee, Myungmo; Zhang, Lei; Park, Yohan; Park, Hyeung-Geun
Tetrahedron, 2012 , vol. 68, # 5 p. 1452 - 1459
反应条件
1: ethanol; NH3 2: SnCl2; aqueous HCl; ethanol View Scheme
参考文献
Jagupol'skii; Troizkaja
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2730,2735, 2736; engl. Ausg. S. 2697, 2701
