2-溴-5-硝基三氟甲苯合成路线 （共 12 条）
反应条件
sulfuric acid; nitric acid
参考文献
McBee et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3932
反应条件
1: liq. NH3 2: (i) aq. NaNO2, aq. HBr, (ii) CuBr, aq. HBr View Scheme
参考文献
Filler,R.; Novar,H.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2707 - 2710
反应条件
1: HNO3, H2SO4 2: liq. NH3 3: (i) aq. NaNO2, aq. HBr, (ii) CuBr, aq. HBr View Scheme
参考文献
Filler,R.; Novar,H.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2707 - 2710
反应条件
(i) aq. NaNO2, aq. HBr, (ii) CuBr, aq. HBr; Multistep reaction;
参考文献
Filler,R.; Novar,H.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2707 - 2710
反应条件
nickel T=140°C; 4 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/51366 A2, 2005 ;
Location in patent: Page/Page column 109 ;
WO 2005/051366 A2
反应条件
in N,N-dimethyl-formamide T=160°C; 18 h;
参考文献
Seo, Myungeun; Seo, Gon; Sang, Youl Kim
Angewandte Chemie - International Edition, 2006 , vol. 45, # 38 p. 6306 - 6310
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
McBee et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3932
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; water; caesium carbonate in tetrahydrofuran Suzuki coupling reaction; Heating;
参考文献
Molander, Gary A.; Yun, Chang-Soo; Ribagorda, Maria; Biolatto, Betina
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5534 - 5539
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in 1,4-dioxane Suzuki-Miyaura coupling; 23 h; Heating;
参考文献
Gray; Andrews; Hook; Kitteringham; Voyle
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6237 - 6240
反应条件
1: SnCl2; aq.-ethanolic HCl 2: aqueous sulfuric acid; sodium nitrite / Erwaermen der Reaktionsloesung mit Kaliumjodid und Kupfer-Pulver View Scheme
参考文献
McBee et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3932
