4-氟-3-硝基苯甲酸乙酯合成路线 （共 20 条）
反应条件
1: triethylamine / methanol / 1 h / |Cooling with ice 2: 5 palladium on charcoal; hydrogen / methanol / 20 °C 3: 2 h / |Reflux View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: triethylamine / methanol / 1 h / |Cooling with ice 2: 5 palladium on charcoal; hydrogen / methanol / 20 °C View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: K2CO3 / dimethylsulfoxide / 20 °C 2: H2 / Pd/C / ethanol / 760 Torr View Scheme
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
反应条件
1: triethylamine / methanol / 1 h / |Cooling with ice 2: 5 palladium on charcoal; hydrogen / methanol / 20 °C 3: 2 h / |Reflux 4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / |Cooling with ice; |Inert atmosphere View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: triethylamine / ethanol / 2 h / 20 °C / |Cooling with ice
2: 5 palladium on charcoal; hydrogen / methanol / 20 °C
View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
in N,N-dimethyl-formamide
T=60°C; 4 h;
参考文献
MERCK SERONO S.A.
Patent: WO2009/43890 A1, 2009 ;
Location in patent: Page/Page column 58-59 ;
WO 2009/043890 A1
反应条件
potassium carbonate in dimethyl sulfoxide
T=20°C;
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2: 10 Pd/C; ammonium formate / ethanol / 0.03 h / 100 °C / |Microwave irradiation
View Scheme
参考文献
Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Osman, Hasnah; Parang, Keykavous; Shirazi, Amir Nasrolahi
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 703 - 710
反应条件
1: 92 percent / Cs2CO3 / dimethylformamide / 2 h / 40 °C
2: LiOH / tetrahydrofuran; H2O / 2 h / 60 °C
3: 2.3 g / hydrogen / Pd/C; PtO2 / methanol / 16 h
4: 91 percent / CDI / tetrahydrofuran / 16 h / 20 °C
View Scheme
参考文献
Ottesen, Lars K.; Ek, Fredrik; Olsson, Roger
Organic Letters, 2006 , vol. 8, # 9 p. 1771 - 1773
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2: ammonium formate; palladium 10 on activated carbon / 0.03 h / 100 °C / |Microwave irradiation
View Scheme
参考文献
Abdul Rahim, Aisyah Saad; Muhamad Salhimi, Salizawati; Arumugam, Natarajan; Pin, Lim Chung; Yee, Ng Shy; Muttiah, Nithya Niranjini; Keat, Wong Boon; Abd. Hamid, Shafida; Osman, Hasnah; Mat, Ishak B.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 6 p. 1255 - 1260
