4-氟-3-硝基三氟甲苯合成路线 （共 42 条）
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride in sulfolane T=130°C; 3 h;
参考文献
Maggini, Michele; Passudetti, Margherita; Gonzales-Trueba, Guadalupe; Prato, Maurizio; Quintily, Ugo; Scorrano, Gianfranco
Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6406 - 6411
反应条件
sulfuric acid; nitric acid T=50 - 60°C;
参考文献
Kuhn,J.; Olah,G.A.
Journal of the American Chemical Society, 1961 , vol. 83, p. 4564 - 4571
反应条件
potassium fluoride; water; N,N-dimethyl-formamide T=160°C;
参考文献
Finger; Kruse
Journal of the American Chemical Society, 1956 , vol. 78, p. 6034,6037
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride in sulfolane T=180°C;
参考文献
Maggini, Michele; Passudetti, Margherita; Gonzales-Trueba, Guadalupe; Prato, Maurizio; Quintily, Ugo; Scorrano, Gianfranco
Journal of Organic Chemistry, 1991 , vol. 56, # 22 p. 6406 - 6411
反应条件
1: PCl5 / Einleiten von Chlor 2: anhydrous HF / 85 °C 3: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
1: anhydrous HF / 85 °C 2: concentrated H2SO4; concentrated aqueous HNO3 / 50 - 60 °C View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
1: methanol. KOH 2: tin; aqueous hydrochloric acid View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
反应条件
in dimethyl sulfoxide T=50°C;
参考文献
MERCK PATENT GMBH
Patent: WO2004/37789 A2, 2004 ;
Location in patent: Page 311 ;
WO 2004/037789 A2
反应条件
1: N,N-dimethyl-formamide With ammonia in water T=240°C; 0.666667 h; 2: 1-fluoro-2-nitro-4-trifluoromethylbenzene in water T=30°C; 0.333333 h;
参考文献
Petersen, Trine P.; Larsen, Anders Foller; Ritzen, Andreas; Ulven, Trond
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4190 - 4195
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. Spl. 113
