4-氟-3-硝基三氟甲苯合成路线 （共 42 条）
反应条件
hydrogenchloride; stannous chloride; sodium hydrogencarbonate in methanol
参考文献
KinoPharma, Inc.
Patent: EP2279750 A1, 2011 ;
EP 2279750 A1
反应条件
hydrogenchloride; sodium hydrogencarbonate in methanol; diethyl ether
参考文献
OTSUKA CHEMICAL COMPANY, LIMITED
Patent: EP1243584 A1, 2002 ;
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran 12 h; Heating / reflux; 2: With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2006/44823 A2, 2006 ;
Location in patent: Page/Page column 146 ;
WO 2006/044823 A2
反应条件
1: ethanol / Heating 2: Fe; aq. HCl / ethanol / Heating View Scheme
参考文献
Seth, Punit P.; Robinson, Dale E.; Jefferson, Elizabeth A.; Swayze, Eric E.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7303 - 7306
反应条件
caesium carbonate; trimethylphosphane; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; ethylene glycol dimethyl ether Suzuki reaction; 16 h; Heating;
参考文献
Widdowson, David A.; Wilhelm, Rene
Chemical Communications, 2003 , # 5 p. 578 - 579
反应条件
1: 1H-imidazole With potassium tert-butylate in dimethyl sulfoxide 0.0833333 h; 2: 1-fluoro-2-nitro-4-trifluoromethylbenzene in dimethyl sulfoxide T=20°C; 0.341667 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)
Patent: WO2009/77766 A1, 2009 ;
Location in patent: Page/Page column 196 ;
WO 2009/077766 A1
反应条件
4-methyl-morpholine in N,N-dimethyl-formamide T=125°C; 16 h;
参考文献
Yun, Young K.; Porco Jr., John A.; Labadie, Jeff
Synlett, 2002 , # 5 p. 739 - 742
参考文献
ASAHI GLASS COMPANY LTD.
Patent: EP163230 B2, 1996 ;
反应条件
tetrabutylammomium bromide in acetonitrile T=20 - 80°C; 13 h; Product distribution / selectivity;
参考文献
Bayer CropScience S.A.
Patent: US6635780 B1, 2003 ;
Location in patent: Page/Page column 7 ;
反应条件
in acetonitrile T=20 - 80°C; 6 h; Product distribution / selectivity;
参考文献
Bayer CropScience S.A.
Patent: US6635780 B1, 2003 ;
Location in patent: Page/Page column 6-7 ;
