1: With sodium methylate in dimethyl sulfoxide T=110°C; 2 h; 2: With water in dimethyl sulfoxide; acetonitrile T=15°C; 3: With hydrogenchloride in water; dimethyl sulfoxide; acetonitrile T=20°C; pH=7.9;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/111046 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;