6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮合成路线 （共 24 条）
反应条件
sodium hydroxide T=90°C;
参考文献
WO2011/7123 A1, ;
Page/Page column 12 ;
反应条件
hydrazine hydrate in ethanol 3 h; Heating;
参考文献
Wang, Teng; Dong, Ying; Wang, Li-Chen; Chen, Zhen
Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 10 p. 641 - 646
反应条件
1: 1.) HCl/EtOH, 2.) 6N aq. HCl / 2 h / Heating; 1.) reflux, 2 h, 2.) reflux, 2 h 2: 87 percent / hydrazine hydrate / H2O / 1.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 62 percent / H2O / 1) room temperature, overnight, 2) steam bath, 2 h 2: conc. H2SO4 / 1 h / Heating 3: pyridine 4: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr 5: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating 6: 76 percent / 1 M aq. HCl / 1.25 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
1: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr 2: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating 3: 76 percent / 1 M aq. HCl / 1.25 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
1: pyridine 2: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr 3: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating 4: 76 percent / 1 M aq. HCl / 1.25 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
1: conc. H2SO4 / 1 h / Heating 2: pyridine 3: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr 4: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating 5: 76 percent / 1 M aq. HCl / 1.25 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
hydrogenchloride 1.25 h; Heating;
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 1) NaH / 1) DMF, room temperature, overnight, 2) DMF, 110 deg C, 3 h 2: 1.) HCl/EtOH, 2.) 6N aq. HCl / 2 h / Heating; 1.) reflux, 2 h, 2.) reflux, 2 h 3: 87 percent / hydrazine hydrate / H2O / 1.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating 2: 76 percent / 1 M aq. HCl / 1.25 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
