6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮合成路线 （共 24 条）
反应条件
1: 61 percent / AlCl3 / CH2Cl2 / Ambient temperature; overnight 2: 1) NaH / 1) DMF, room temperature, overnight, 2) DMF, 110 deg C, 3 h 3: 1.) HCl/EtOH, 2.) 6N aq. HCl / 2 h / Heating; 1.) reflux, 2 h, 2.) reflux, 2 h 4: 87 percent / hydrazine hydrate / H2O / 1.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1689 - 1695
反应条件
1.1: bromine / chloroform 1.2: 24 h / 20 °C / pH 8 2.1: sodium ethanolate / ethanol / Cooling with ice 2.2: 8.17 h / 35 - 75 °C 3.1: sodium hydroxide / water / 4 h 3.2: 3 h / 100 °C / pH 1 View Scheme
参考文献
Medicinal Chemistry Research, , vol. 20, # 3 p. 287 - 292
反应条件
1.1: sodium ethanolate / ethanol / Cooling with ice 1.2: 8.17 h / 35 - 75 °C 2.1: sodium hydroxide / water / 4 h 2.2: 3 h / 100 °C / pH 1 View Scheme
参考文献
Medicinal Chemistry Research, , vol. 20, # 3 p. 287 - 292
参考文献
Orion Corporation
Patent: US6180789 B2, 2001 ;
反应条件
1: in ethanol; water T=15 - 65°C; 1.5 h; 2: With potassium carbonate in water T=25°C; pH=8 - 9; 0.5 h;
参考文献
CIPLA LIMITED; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; PHULL, Manjinder, Singh; SAWANT, Ashwini, Amol; CURTIS, Philip, Anthony
Patent: WO2011/7123 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
in ethanol; water T=15 - 65°C;
参考文献
CIPLA LIMITED; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; PHULL, Manjinder, Singh; SAWANT, Ashwini, Amol; CURTIS, Philip, Anthony
Patent: WO2011/7123 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With L-(+)-tartaric acid in isopropyl alcohol 0.5 h; HeatingResolution of racemate; 2: With potassium carbonate in water pH=7 - 8; Resolution of racemate; 3: in 1,4-dioxane 0.5 h; RefluxResolution of racemate;
参考文献
Wang, Lisheng; Zhou, Hongxiang; Yang, Bin; Chen, Zhigang; Yang, Hua
Medicinal Chemistry Research, 2011 , vol. 20, # 3 p. 287 - 292
反应条件
1: OR-1855 With hydrogenchloride; sodium nitrite in water 0.166667 h; 2: malononitrile in water T=20°C; 1 h; 3: With sodium acetate in water pH=6;
参考文献
CIPLA LIMITED; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; PHULL, Manjinder, Singh; SAWANT, Ashwini, Amol; CURTIS, Philip, Anthony
Patent: WO2011/7123 A1, 2011 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1.1: ethanol; water / 1.5 h / 15 - 65 °C 2.1: ammonia / water / 0.5 h / 25 - 30 °C / pH 8 - 9 3.1: hydrogenchloride; sodium nitrite / water / 0.17 h 3.2: 1 h / 20 °C 3.3: pH 6 View Scheme
参考文献
CIPLA LIMITED; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; PHULL, Manjinder, Singh; SAWANT, Ashwini, Amol; CURTIS, Philip, Anthony
Patent: WO2011/7123 A1, 2011 ;
参考文献
Smith Kline and French Laboratories Limited
Patent: US4906628 A1, 1990 ;
US 4906628 A
