2,4-二氯-6-甲基嘧啶-5-羧酸甲酯合成路线 （共 2 条）
反应条件
trichlorophosphate; N,N-dimethyl-aniline
T=105°C; 6 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/152273 A1, 2011 ;
Location in patent: Page/Page column 28 ;
反应条件
1: diethyl ether / 4 h / 0 - 5 °C
2: triethylamine / water / 21 h / 50 - 60 °C
3: tributyl-amine; trichlorophosphate / 3 h / 95 °C
View Scheme
参考文献
GRÜNENTHAL GMBH; LUCAS, Simon; Kühnert, Sven; Bahrenberg, Gregor; Schröder, Wolfgang
Patent: US2014/148454 A1, 2014 ;
