4-(4-羟基哌啶-1-基)哌啶-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
1: With acetic acid in dichloromethane
T=20°C; 3 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane
T=20°C; 18 h;
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M.; HILFIKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119701 A1, 2011 ;
Location in patent: Page/Page column 38 ;
WO 2011/119701 A1
反应条件
1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / 2.5 h / -78 - 20 °C
2: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M.; HILFIKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119701 A1, 2011 ;
WO 2011/119701 A1
