N-(2-氯乙基)-2-氧代-1-氧杂-3-氮杂-2-磷杂环己烷-2-胺合成路线 （共 12 条）
反应条件
1: aq. HCl / diethyl ether 2: H2 / Pd-C / ethanol View Scheme
参考文献
Pankiewicz,K. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 7712 - 7718
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Pankiewicz,K. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 7712 - 7718
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Pankiewicz,K. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 7712 - 7718
反应条件
sodium tetrahydroborate in isopropyl alcohol 0.666667 h;
参考文献
Misiura, Konrad
Pharmazie, 2004 , vol. 59, # 9 p. 668 - 672
反应条件
triethylamine; trichlorophosphate in dichloromethane
参考文献
Takamizawa; Iwata; Matsumoto
Chemical and Pharmaceutical Bulletin, 1977 , vol. 25, # 11 p. 2900 - 2909
反应条件
human liver microsomes in phosphate buffer T=37°C; dealkylation; pH=7.8; 0.5 h; Enzymatic reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
Bohnenstengel; Hofmann; Eichelbaum; Kroemer
European Journal of Clinical Pharmacology, 1996 , vol. 51, # 3-4 p. 297 - 301
反应条件
1: tetrahydrofuran 2: B2H6 / tetrahydrofuran View Scheme
参考文献
Pankiewicz,K. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 7712 - 7718
参考文献
Pankiewicz,K. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 7712 - 7718
反应条件
hydrogenchloride 24 h; Ambient temperature;
参考文献
Gilard, Veronique; Martino, Robert; Malet-Martino, Myriam; Niemeyer, Ulf; Pohl, Joerg
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2542 - 2560
参考文献
Gilard, Veronique; Martino, Robert; Malet-Martino, Myriam; Niemeyer, Ulf; Pohl, Joerg
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2542 - 2560
