4-(2-羟基乙酰基)苯甲腈合成路线 （共 7 条）
反应条件
hydrogen; chiral iridium(III) complex in methanol T=60°C; P=7600.51 Torr; 15 h; Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 9, # 13 p. 2564 - 2567
反应条件
HCO2Cs in methanol
2 h; RefluxInert atmosphere;
参考文献
Wong, Fung Fuh; Chang, Po-Wei; Lin, Hui-Chang; You, Bang-Jau; Huang, Jiann-Jyh; Lin, Shao-Kai
Journal of Organometallic Chemistry, 2009 , vol. 694, # 21 p. 3452 - 3455
反应条件
trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene in water; acetonitrile
18 h; Reflux;
参考文献
MERCK SERONO S.A.; BOMBRUN, Agnes; QUATTROPANI, Anna; GONZALEZ, Jerome; DORBAIS, Jerome; KNIGHT, Chris; BAKER-GLENN, Charles
Patent: WO2012/4287 A1, 2012 ;
Location in patent: Page/Page column 90 ;
WO 2012/004287 A1
反应条件
hydrogenchloride; water in methanol
T=40°C; Inert atmosphere;
参考文献
McLaughlin, Mark; Belyk, Kevin M.; Qian, Gang; Reamer, Robert A.; Chen, Cheng-Yi
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5144 - 5148
反应条件
in acetone
T=25°C; 3 h;
参考文献
Kovac, F.; Baumstark, A. L.
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8751 - 8754
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 20 - 30 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
1.3: 30 °C / Inert atmosphere
2.1: hydrogenchloride; water / methanol / 40 °C / Inert atmosphere
View Scheme
参考文献
McLaughlin, Mark; Belyk, Kevin M.; Qian, Gang; Reamer, Robert A.; Chen, Cheng-Yi
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5144 - 5148
反应条件
sodium ethanolate in ethanol
参考文献
Kaspersen, Svein Jacob; Hoff, Bard Helge; Sundby, Eirik; Charnock, Colin
Bioorganic Chemistry, 2012 , vol. 44, p. 35 - 41,7
