6-乙基-4-羟基-2H-吡喃-2-酮合成路线 （共 7 条）
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Deshpande; Khan; Ayyanagar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 8 p. 790 - 793
反应条件
trifluoroacetic acid; trifluoroacetic anhydride
T=0 - 20°C;
参考文献
ACTIVX BIOSCIENCES, INC.; KYORIN DISCOVERY RESEARCH LABORATORIES
Patent: WO2008/36379 A2, 2008 ;
Location in patent: Page/Page column 71-72 ;
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; hexane
T=20°C; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
type III polyketide synthase RppA from S. griseus; 2-hydroxyethanethiol in various solvent(s)
T=37°C; pH=7.5; 2 h;
参考文献
Jeong, Jae-Cheol; Srinivasan, Aravind; Grueschow, Sabine; Bach, Horacio; Sherman, David H.; Dordick, Jonathan S.
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 64 - 65
反应条件
AuNTf2(SPhos); acetic acid
T=20°C; 24 h; Inert atmosphere;
参考文献
Chaladaj, Wojciech; Corbet, Matthieu; Fuerstner, Alois
Angewandte Chemie - International Edition, 2012 , vol. 51, # 28 p. 6929 - 6933
反应条件
1: 81 percent / potassium hydroxide / ethanol / 0.5 h / 20 °C
2: 77 percent / TFA / various solvent(s) / 2 h / 0 °C
View Scheme
参考文献
Schmidt, Dietmar; Conrad, Juergen; Klaiber, Iris; Beifuss, Uwe
Chemical Communications, 2006 , # 45 p. 4732 - 4734
参考文献
Doundoulakis, Thomas; Xiang, Alan X.; Lira, Ricardo; Agrios, Konstantinos A.; Webber, Stephen E.; Sisson, Wes; Aust, Robert M.; Shah, Amit M.; Showalter, Richard E.; Appleman, James R.; Simonsen, Klaus B.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5667 - 5672
