2,4-二氟-5-甲基苯甲酸合成路线 （共 3 条）
反应条件
sulfuric acid 1 h; Heating;
参考文献
Shibata; Biplab Kumar Das; Honjo; Takeuchi
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 14 p. 1605 - 1611
反应条件
1: 50 percent / dimethylformamide / 3 h / 160 °C 2: 100 percent / aq. H2SO4 / 1 h / Heating View Scheme
参考文献
Shibata; Biplab Kumar Das; Honjo; Takeuchi
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 14 p. 1605 - 1611
反应条件
1: thionyl chloride / methanol / 3 h / 50 °C / |Cooling with ice 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C / |Cooling with acetone-dry ice View Scheme
参考文献
CONFLUENCE LIFE SCIENCES, INC.; SELNESS, Shaun R.; Devadas, Balekudru; Hockerman, Susan L.; Monahan, Joseph B.
Patent: US2013/143906 A1, 2013 ;
