2-甲基-1H-吲哚-5-甲腈合成路线 （共 6 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5 - 7°C; 1.5 h; Reflux; 2: With water; sodium hydroxide in tetrahydrofuran 0.166667 h; Cooling with ice;
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen
Patent: WO2014/49133 A1, 2014 ;
Location in patent: Page/Page column 30 ;
反应条件
methanol; sodium hydroxide in tetrahydrofuran
T=0 - 20°C;
参考文献
LG LIFE SCIENCES LTD.; CHOI, Sung Pil; KIM, Geun Tae; SONG, Jeong Uk; KIM, Tae Hun; LIM, Dong Chul; KANG, Seung Wan; KIM, Hyung Jin
Patent: WO2010/93191 A2, 2010 ;
Location in patent: Paragraph 822-826 ;
WO 2010/093191 A2
反应条件
in quinoline
1 h; Reflux; Product distribution / selectivity;
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen
Patent: WO2014/49133 A1, 2014 ;
Location in patent: Page/Page column 30 ;
反应条件
1: 85 percent / tert-butyl hypochlorite / CH2Cl2 / 1.) -70 deg C, 20 min 2.) -70 deg C, 1.5 h,
2: 83 percent / thiosalicylic acid / trifluoroacetic acid / 0.25 h / Ambient temperature
View Scheme
参考文献
Hamel, Pierre; Zajac, Nicolas; Atkinson, Joseph G.; Girard, Yves
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6372 - 6377
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere
1.2: 2 h / -78 °C
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 0 °C
View Scheme
参考文献
H. Lundbeck A/S
Patent: US2012/252853 A1, 2012 ;
US 20120252853 A1
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
1.2: 15 h / 0 - 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere
2.2: 2 h / -78 °C
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 0 °C
View Scheme
参考文献
H. Lundbeck A/S
Patent: US2012/252853 A1, 2012 ;
US 20120252853 A1
