[(2-甲基-1H-吲哚-5-基)甲基]胺合成路线 （共 7 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5 - 7°C; 1.5 h; Reflux; 2: With water; sodium hydroxide in tetrahydrofuran 0.166667 h; Cooling with ice;
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen
Patent: WO2014/49133 A1, 2014 ;
Location in patent: Page/Page column 30 ;
反应条件
hydrazine hydrate in methanol 1.5 h; Heating;
参考文献
Muminov, A.; Yudin, L. G.; Zinchenko, E. Ya.; Romanova, N. N.; Kost, A. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1012 - 1015
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1218 - 1221
反应条件
1.1: quinoline / 1 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 5 - 7 °C / Reflux 2.2: 0.17 h / Cooling with ice View Scheme
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen
Patent: WO2014/49133 A1, 2014 ;
反应条件
1: 96 percent / H2SO4 / 30 h / Ambient temperature 2: 92 percent / N2H4*H2O / methanol / 1.5 h / Heating View Scheme
参考文献
Muminov, A.; Yudin, L. G.; Zinchenko, E. Ya.; Romanova, N. N.; Kost, A. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1012 - 1015
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1218 - 1221
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere 1.2: 2 h / -78 °C 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 0 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 5 - 7 °C / Reflux 3.2: 0.17 h / Cooling with ice View Scheme
参考文献
H. Lundbeck A/S
Patent: US2012/252853 A1, 2012 ;
US 20120252853 A1
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C 1.2: 15 h / 0 - 20 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere 2.2: 2 h / -78 °C 3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 0 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 5 - 7 °C / Reflux 4.2: 0.17 h / Cooling with ice View Scheme
参考文献
H. Lundbeck A/S
Patent: US2012/252853 A1, 2012 ;
US 20120252853 A1
反应条件
1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 0 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 5 - 7 °C / Reflux 2.2: 0.17 h / Cooling with ice View Scheme
参考文献
H. Lundbeck A/S
Patent: US2012/252853 A1, 2012 ;
US 20120252853 A1
