3,4-二胺基苄氧基三氟化物合成路线 （共 35 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; 4 h;
参考文献
Takano, Yasuo; Shiga, Futoshi; Asano, Jun; Hori, Wataru; Fukuchi, Kazunori; Anraku, Tsuyoshi; Uno, Takashi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 776 - 792
反应条件
methanol; palladium on activated charcoal Hydrogenation;
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
stannous chloride in ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
palladium on charcoal in ethanol
参考文献
Eli Lilly and Company
Patent: US3962440 A1, 1976 ;
反应条件
1: (R)-5-(1-(tert-butoxycarbonylamino)ethyl)isoxazole-3-carboxylic acid With triethylamine; isobutyl chloroformate in tetrahydrofuran T=-20°C; 1 h; 2: 4-(trifluoromethyl)-1,2-phenylenediamine in tetrahydrofuran T=-20 - 20°C; 4 h; 3: With water; sodium carbonate; acetic acid more than 3 stages;
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 88 ;
US 20090036419 A1
反应条件
1: 28 percent / ethanol / 1 h / Heating 2: 80 percent / POCl3 / 5 h / 70 °C View Scheme
参考文献
Loriga; Piras; Sanna; Paglietti
Farmaco, 1997 , vol. 52, # 3 p. 157 - 166
反应条件
1: aq. SeO2 / ethanol / 0.5 h / Heating 2: concd. H2SO4, concd. HNO3 / 1 h / 10 °C 3: concd. HCl, 48percent HI / 2 h / Ambient temperature View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: 31 percent / ethanol / 1 h / Heating 2: 85 percent / POCl3 / 5 h / 70 °C View Scheme
参考文献
Loriga; Piras; Sanna; Paglietti
Farmaco, 1997 , vol. 52, # 3 p. 157 - 166
参考文献
Byk Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung
Patent: US4472409 A1, 1984 ;
反应条件
in ethanol; water 8 h; Heating;
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
