3-氧代-3,4-二氢-2-喹喔啉甲酸乙酯合成路线 （共 19 条）
反应条件
1: POCl3 2: aqueous methanol.NaCN 3: 160 °C / 1 Torr 4: ethanol; NH3 View Scheme
参考文献
Gowenlock et al.
Journal of the Chemical Society, 1945 , p. 622,625
反应条件
1: POCl3 2: aqueous methanol.NaCN View Scheme
参考文献
Mahesh, Radhakrishnan; Devadoss, Thangaraj; Pandey, Dilip Kumar; Bhatt, Shvetank
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1253 - 1256
反应条件
2: aq. NaOH solution View Scheme
参考文献
Ohle; Gross
Chemische Berichte, 1935 , vol. 68, p. 2262,2266
反应条件
1: POCl3 2: ethanol 3: aq.-ethanolic KOH View Scheme
参考文献
Mahesh, Radhakrishnan; Devadoss, Thangaraj; Pandey, Dilip Kumar; Bhatt, Shvetank
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1253 - 1256
反应条件
1: POCl3
2: aqueous methanol.NaCN
3: 160 °C / 1 Torr
4: ethanol; NH3
View Scheme
参考文献
Gowenlock et al.
Journal of the Chemical Society, 1945 , p. 622,625
反应条件
1: N,N-dimethyl-formamide; trichlorophosphate / 0.5 h / |Reflux
2: sodium carbonate / water; methanol / 6 h / |Reflux
3: sodium methylate / 0.1 h / |Reflux; |Microwave irradiation
View Scheme
参考文献
Mahesh, Radhakrishnan; Devadoss, Thangaraj; Dhar, Arghya Kusum; Venkatesh, Sudali Muthu; Mundra, Sourabh; Pandey, Dilip Kumar; Bhatt, Shvetank; Jindal, Ankur Kumar
Archiv der Pharmazie, 2012 , vol. 345, # 9 p. 687 - 694
反应条件
1: POCl3
2: ethanol
3: aq.-ethanolic KOH
4: 180 °C
View Scheme
参考文献
Gowenlock et al.
Journal of the Chemical Society, 1945 , p. 622,625
反应条件
sodium hydride
1.) mineral oil, DMF, r.t., 40 min: 2.) ref., 6 h;
参考文献
Harayama, Takashi; Tezuka, Yasuhiro; Taga, Tooru; Yoneda, Fumio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 75 - 84
反应条件
1: 89 percent / (NH4)2CO3 / methanol / Ambient temperature
2: 85 percent / PCl5, POCl3 / 1.5 h / 110 °C
3: 83 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Yoshida, Kei; Otomasu, Hirotaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
